Ortega is a neighborhood of Jacksonville, Florida, US. It is located south of downtown Jacksonville on a peninsula off the western bank of the St. Johns River. It is one of the wealthiest neighborhoods in Jacksonville, and is the location of many historic homes and buildings.
The peninsula containing Ortega is bounded by the St. Johns and Ortega Rivers, and is bisected by Roosevelt Boulevard (U.S. Route 17); the area to the east of Roosevelt is known as Old Ortega, while the area to the west is known as Ortega Forest. On July 14, 2004, a section of Ortega to the east of 17 and north of Verona Boulevard was designated as the Old Ortega Historic District by the National Register of Historic Places.